Research

Current Research Programs - Last updated 6/9/06

Stem Cell Engineering

We are interested in understanding the structure/function relationship of biomaterials for the differentiation, migration, and proliferation of human embryonic stem cells. Our approach is to construct biomimetic environments that imitate /in vivo /extracellular matrices (ECM). The ECM is a complex, three-dimensional environment that surrounds and supports cells in tissues. It is comprised of structural proteins (like collagen and elastin), specialized proteins (like fibronectin and laminin), and proteoglycans. In addition, growth factors, cytokines, and other soluble factors affect the spatio-temporal microenvironment in which cells are directed into a specific lineage. We investigate both natural and synthetic mimics of the ECM. These environments are further specialized through surface modification, mechanical stresses, and controlled release of factors locally. We utilize a wide range of tools to look at two and three-dimensional systems for potential use in cell-based therapies.

Tissue Engineering

The field of tissue engineering is inundated with different approaches to repair or replace tissues. There lies a wealth of opportunity in the development and modeling of diseased tissues. We are in the process of creating a new paradigm in tissue engineering whereby we design tissue models that mimic diseased states. These models will provide an advantage in screening pharmaceuticals and will advance our knowledge of how we treat and think about diseased tissues.

Drug Delivery

How much, where, and when we deliver a drug is essential to patient care. The therapeutic index of a drug is measured as the ratio of the efficiency to toxicity. By changing the biodistribution and intracellular uptake, the toxic effects of a drug can be lessened. This is often critical in elderly, immune compromised, and cancer patients, for example. We are interested in methods to reduce immune recognition and increase site-specific localization to improve the amount of drug delivered, toxicity, and cost. Our research focuses on polymeric and liposome based drug delivery. These nanoparticles effectively localize in tumors and in sites of inflammation. Interfering RNA (RNAi) and gene delivery are also of interest as they have important implications in localized therapies.